CD1d deficiency limits tolerogenic properties of peritoneal macrophages
نویسندگان
چکیده
منابع مشابه
Effect of Ganoderma Lucidum on Cytokine Release by Peritoneal Macrophages
Background: The water-soluble extract of Ganoderma lucidum (Reishi) has been used as an immunomodulator to stimulate spleen cells proliferation and cytokine expression. Objective: To investigate the effect of Ganoderma lucidum (G. lucidum) on cytokine production by mice peritoneal macrophages. Methods: Mice peritoneal macrophages were prepared by intra-peritoneal injection of 5 ml cold PBS. Per...
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BACKGROUND Dendritic cells (DC) can act tolerogenic at a semi-mature stage by induction of protective CD4(+) T cell and NKT cell responses. METHODOLOGY/PRINCIPAL FINDINGS Here we studied the role of the co-inhibitory molecule B7-H1 (PD-L1, CD274) on semi-mature DC that were generated from bone marrow (BM) cells of B7-H1(-/-) mice and applied to the model of Experimental Autoimmune Encephalomy...
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Invariant natural killer T cells (iNKTs) are innate-like T cells that are highly concentrated in the liver and recognize lipids presented on the MHC-like molecule CD1d. Although capable of a myriad of responses, few essential functions have been described for iNKTs. Among the many cell types of the immune system implicated in metabolic control and disease, iNKTs seem ideally poised for such a r...
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Patients undergoing CAPD are prone to episodes of peritonitis caused principally by infection with Staphylococcus epidermidis. Since macrophages are believed to be of prime importance in protection of the peritoneal cavity we have examined certain activities of CAPD peritoneal macrophages and compared them with normal peritoneal macrophages and blood monocytes. CAPD macrophages were obtained fr...
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Objective(s) Shark Liver Oil (SLO) is an immunomodulator. Macrophages play a key role in host defense against pathogens like fungi. Candida albicans have mechanisms to escape immune system. We determined the effect of killed-Candida on the in vitro viability of macrophages and the effect of SLO on augmentation of this potency. Materials and Methods Peritoneal macrophages were separated and c...
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ژورنال
عنوان ژورنال: BMB Reports
سال: 2021
ISSN: 1976-670X
DOI: 10.5483/bmbrep.2021.54.4.183